1,4-Butanediol → Tert-butyl 2-(4-hydroxybutoxymethyl)-6-methylbenzoate

반응식

Br[CH2:2][C:3]1[CH:15]=[CH:14][CH:13]=[C:12]([CH3:16])[C:4]=1[C:5]([O:7][C:8]([CH3:11])([CH3:10])[CH3:9])=[O:6].[CH2:17]([OH:22])[CH2:18][CH2:19][CH2:20][OH:21].OCCCOCC1C=CC=C(C)C=1C(OC(C)(C)C)=O>>[OH:21][CH2:20][CH2:19][CH2:18][CH2:17][O:22][CH2:2][C:3]1[CH:15]=[CH:14][CH:13]=[C:12]([CH3:16])[C:4]=1[C:5]([O:7][C:8]([CH3:11])([CH3:10])[CH3:9])=[O:6]

참가 물질

반응물 3

HCID 80641,4-Butanediol

HCID 59341259Tert-butyl 2-(3-hydroxypropoxymethyl)-6-methylbenzoate

HCID 59341261tert-Butyl 2-(bromomethyl)-6-methylbenzoate

생성물 1

HCID 59341263Tert-butyl 2-(4-hydroxybutoxymethyl)-6-methylbenzoate

실험 절차

tert-Butyl 2-(4-hydroxybutoxymethyl)-6-methylbenzoate is prepared from tert-butyl 2-bromomethyl-6-methylbenzoate and butane-1,4-diol in analogy to the synthesis of tert-butyl 2-(3-hydroxypropoxymethyl)-6-methylbenzoate.

출처 및 근거

ORD 기록: ord-a3f13bbb3b6247e4939028582f7ce2db
출처 데이터셋: uspto-grants-2010_06
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07732471B2

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