2-Chloro-4-fluoro-1-iodobenzene → N-[3-(1-{[1-(2-Chloro-4-fluorophenyl)-1H-indol-4-YL]methyl}-4-piperidinyl)phenyl]-2-methylpropanamide

반응식

[Cl:1][c:2]1[c:3]([I:9])[cH:4][cH:5][c:6]([F:8])[cH:7]1.[nH:10]1[cH:11][cH:12][c:13]2[c:14]([CH2:19][N:20]3[CH2:21][CH2:22][CH:23]([c:26]4[cH:27][c:28]([NH:32][C:33]([CH:34]([CH3:35])[CH3:36])=[O:37])[cH:29][cH:30][cH:31]4)[CH2:24][CH2:25]3)[cH:15][cH:16][cH:17][c:18]12>>[Cl:1][c:2]1[c:3](-[n:10]2[cH:11][cH:12][c:13]3[c:14]([CH2:19][N:20]4[CH2:21][CH2:22][CH:23]([c:26]5[cH:27][c:28]([NH:32][C:33]([CH:34]([CH3:35])[CH3:36])=[O:37])[cH:29][cH:30][cH:31]5)[CH2:24][CH2:25]4)[cH:15][cH:16][cH:17][c:18]23)[cH:4][cH:5][c:6]([F:8])[cH:7]1

참가 물질

반응물 2

HCID 27365592-Chloro-4-fluoro-1-iodobenzene

HCID 22048637N-(3-[1-(1H-indol-4-ylmethyl)-4-piperidinyl]phenyl}-2-methylpropanamide

생성물 1

HCID 22048956N-[3-(1-{[1-(2-Chloro-4-fluorophenyl)-1H-indol-4-YL]methyl}-4-piperidinyl)phenyl]-2-methylpropanamide

출처 및 근거

ORD 기록: ord-12a934511ae242499b1b1c696bc8e9c4
출처 데이터셋: Training data from https://doi.org/10.1039/C8SC04228D (9/10)
DOI: 10.1039/C8SC04228D

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