Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
4-Methylmorpholine → 5-chloro-thiophene-2-carboxylic acid-N-{1-[3-chloro-4-(pyrrolidin-1-yl-carbonyl)-phenylcarbamoyl]-ethyl}-amide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 4-Methylmorpholine | HCID 7972 | — |
| 반응물 | O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate | HCID 2733207 | — |
| 반응물 | 3-Chloro-4-[(pyrrolidin-1-yl)carbonyl]aniline | HCID 16777853 | — |
| 반응물 | 2-[(5-Chloro-thiophene-2-carbonyl)-amino]-propionic acid | HCID 43239338 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | 5-chloro-thiophene-2-carboxylic acid-N-{1-[3-chloro-4-(pyrrolidin-1-yl-carbonyl)-phenylcarbamoyl]-ethyl}-amide | HCID 11640731 | — |
반응 단계
Prepared analogously to Example 1a from 2-[(5-chloro-thiophene-2-carbonyl)-amino]-propionic acid and 3-chloro-4-(pyrrolidin-1-yl-carbonyl)-aniline with TBTU and NMM in DMF.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07732466B2 |
| 출처 데이터셋 | uspto-grants-2010_06 |
| ORD ID | ord-dcdbdac0a56e40299e8b1ada792d2b70 |
| 출처 메모 | uspto-grants-2010_06 |