Methyl Ethyl Ketone → Methyl 3-methylpent-2-enoate

HRID 1510125노트

반응식

HRID 1510125 반응식
C(OP([CH2:9][C:10]([O:12][CH3:13])=[O:11])(OCC)=O)C.C[O-].[Na+].[CH3:17][C:18](=O)[CH2:19][CH3:20]>O>[CH3:13][O:12][C:10](=[O:11])[CH:9]=[C:18]([CH3:17])[CH2:19][CH3:20]

참가 물질

5

반응물 3

HCID 6569Methyl Ethyl KetoneHCID 66113Methyl diethylphosphonoacetateHCID 10942334Sodium Methoxide

생성물 1

HCID 521288Methyl 3-methylpent-2-enoate

시약·촉매·용매 1

HCID 962Water용매

실험 절차

To a 0° C. mixture of methyl diethylphosphonoacetate (12.7 ml, 69.3 mmol) and sodium methoxide (13.0 ml, 69.3 mmol) was added dropwise 2-butanone (5.81 ml, 69.3 mmol) over 30 min. After the addition, the mixture warmed to rt and stirred overnight. To the reaction was added 20 mL of H2O. The mixture was extracted with EtOAc (3 times). The combined organics were dried with MgSO4, filtered, and concentrated. The crude oil was distilled at 110° C. at 35 mmHg to give the desired product.

후처리

  1. additionAfter the addition
  2. extractionThe mixture was extracted with EtOAc (3 times)
  3. dry with materialThe combined organics were dried with MgSO4
  4. filtrationfiltered
  5. concentrationconcentrated
  6. distillationThe crude oil was distilled at 110° C. at 35 mmHg

출처 및 근거

ORD 기록
ord-8a21c7b5779d480fad1ca79d24454987
출처 데이터셋
uspto-grants-2012_07
특허 번호
US08211904B2

반응 노트

불러오는 중…