Potassium Carbonate → HCID 66790112, 화합물

HRID 1510159노트

반응식

HRID 1510159 반응식
[CH:1]([CH:3]1[CH2:8][C:7](=[O:9])[CH2:6][CH2:5][NH:4]1)=[CH2:2].Cl[CH2:11][C:12]1[CH:17]=[CH:16][CH:15]=[C:14]([O:18][CH:19]([CH3:21])[CH3:20])[CH:13]=1.C([O-])([O-])=O.[K+].[K+]>C(#N)C>[CH:19]([O:18][C:14]1[CH:13]=[C:12]([CH:17]=[CH:16][CH:15]=1)[CH2:11][N:4]1[CH2:5][CH2:6][C:7](=[O:9])[CH2:8][CH:3]1[CH:1]=[CH2:2])([CH3:21])[CH3:20]

참가 물질

5

반응물 3

HCID 11430Potassium CarbonateHCID 205693092-Ethenylpiperidin-4-oneHCID 295411551-(Chloromethyl)-3-isopropoxybenzene

생성물 1

HCID 66790112HCID 66790112, 화합물

시약·촉매·용매 1

HCID 6342Acetonitrile용매

반응 조건

온도
60 °C

실험 절차

2-vinylpiperidin-4-one (4.85 g, 38.7 mmol) in acetonitrile (40 ml) was added 1-(chloromethyl)-3-isopropoxybenzene (7.16 g, 38.7 mmol) and finely ground K2CO3 (16.1 g, 116 mmol). The mixture was stirred at 60° C. for 12 hrs. The solution was filtered, and the solvent was evaporated under reduced pressure. The residue was purified by column chromatography on silica gel Biotage 65i, eluting with 15% ethyl acetate/hexanes.

후처리

  1. filtrationThe solution was filtered
  2. customthe solvent was evaporated under reduced pressure
  3. customThe residue was purified by column chromatography on silica gel Biotage 65i
  4. washeluting with 15% ethyl acetate/hexanes

출처 및 근거

ORD 기록
ord-9f5efcdc2e394b4b9bb9b8bb13a10979
출처 데이터셋
uspto-grants-2012_07
특허 번호
US08211904B2

반응 노트

불러오는 중…