Toluene → 2-(2-Methoxyphenyl)naphthalene

HRID 1510182

반응식

HRID 1510182 반응식
C1COCC1.[CH:6]1[C:15]2[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=2)[CH:9]=[CH:8][C:7]=1[Mg]Br.Cl[C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][C:20]=1[O:25][CH3:26].C1(C)C=CC=CC=1>CCCCCC>[CH3:26][O:25][C:20]1[CH:21]=[CH:22][CH:23]=[CH:24][C:19]=1[C:7]1[CH:8]=[CH:9][C:10]2[C:15](=[CH:14][CH:13]=[CH:12][CH:11]=2)[CH:6]=1

참가 물질

6

반응물 4

HCID 1140TolueneHCID 8028TetrahydrofuranHCID 130112-ChloroanisoleHCID 178418423HCID 178418423, 화합물

생성물 1

HCID 111606562-(2-Methoxyphenyl)naphthalene수율 96%

시약·촉매·용매 1

HCID 8058Hexane용매

실험 절차

Using a THF solution of 2-naphthylmagnesium bromide (1.47 mL, 1.02 M, 1.5 mmol), and 1-chloro-2-methoxybenzene (142.6 mg, 1.0 mmol) as starting materials, the reaction was performed at a scale of 1.0 mmol at 70° C. for 48 hours in the same manner as in Example 2. After performing silica gel column chromatography (toluene=10, 20 and 40% in hexane), the above compound was obtained as a white solid (0.224 g, yield=96%, purity=>99% (GC analysis)).

후처리

  1. customthe above compound was obtained as a white solid (0.224 g, yield=96%, purity=>99% (GC analysis))

출처 및 근거

ORD 기록
ord-37c1d50c0e144af5adab41ca0d0d5980
출처 데이터셋
uspto-grants-2012_07
특허 번호
US08211820B2

연결된 노트

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