HCID 86649454, 화합물 → 3-[2-(3-Isopropoxy-5-phenoxybenzoylamino)-thiazol-5-yl]-propionic acid ethyl ester

HRID 1510311노트

반응식

HRID 1510311 반응식
[CH2:1]([O:3][C:4](=[O:32])[CH:5]=[CH:6][C:7]1[S:11][C:10]([NH:12][C:13](=[O:31])[C:14]2[CH:19]=[C:18]([O:20][C:21]3[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=3)[CH:17]=[C:16]([O:27][CH:28]([CH3:30])[CH3:29])[CH:15]=2)=[N:9][CH:8]=1)[CH3:2].[H][H]>CO.[Pd]>[CH2:1]([O:3][C:4](=[O:32])[CH2:5][CH2:6][C:7]1[S:11][C:10]([NH:12][C:13](=[O:31])[C:14]2[CH:19]=[C:18]([O:20][C:21]3[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=3)[CH:17]=[C:16]([O:27][CH:28]([CH3:29])[CH3:30])[CH:15]=2)=[N:9][CH:8]=1)[CH3:2]

참가 물질

5

반응물 2

HCID 86649454HCID 86649454, 화합물HCID 178418361HCID 178418361, 화합물

생성물 1

HCID 866494553-[2-(3-Isopropoxy-5-phenoxybenzoylamino)-thiazol-5-yl]-propionic acid ethyl ester수율 90%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

3-[2-(3-Isopropoxy-5-phenoxybenzoylamino)-thiazol-5-yl]-propionic acid ethyl ester was prepared in 90% yield from the reduction of 3-[2-(3-isopropoxy-5-phenoxybenzoylamino)-thiazol-5-yl]-acrylic acid ethyl ester in methanol (10 mL) using hydrogen (60 psi) over Pd/C (200 mg).

출처 및 근거

ORD 기록
ord-bd6525bba22b4bfeb6d6db971137f552
출처 데이터셋
uspto-grants-2012_07
특허 번호
US08211925B2

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