Cyclopentylamine → 4-Bromo-5-(4-chlorophenyl)-N-cyclopentylisoxazole-3-carboxamide

HRID 1510427노트

반응식

HRID 1510427 반응식
[Br:1][C:2]1[C:3]([C:14]([O:16]CC)=O)=[N:4][O:5][C:6]=1[C:7]1[CH:12]=[CH:11][C:10]([Cl:13])=[CH:9][CH:8]=1.[CH:19]1([NH2:24])[CH2:23][CH2:22][CH2:21][CH2:20]1>C(O)C>[Br:1][C:2]1[C:3]([C:14]([NH:24][CH:19]2[CH2:23][CH2:22][CH2:21][CH2:20]2)=[O:16])=[N:4][O:5][C:6]=1[C:7]1[CH:8]=[CH:9][C:10]([Cl:13])=[CH:11][CH:12]=1

참가 물질

4

반응물 2

HCID 2906CyclopentylamineHCID 67121165Ethyl 4-bromo-5-(4-chlorophenyl)isoxazole-3-carboxylate

생성물 1

HCID 533260944-Bromo-5-(4-chlorophenyl)-N-cyclopentylisoxazole-3-carboxamide

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

A mixture of ethyl 4-bromo-5-(4-chlorophenyl)isoxazole-3-carboxylate (213 mg, 0.70 mmol) and cyclopentylamine (0.70 mL, 7.0 mmol) in absolute ethanol (8 mL) was heated to reflux overnight. The volatiles were removed in vacuo and the compound was purified by silica gel chromatography eluting with 2% methanol with dichloromethane to afford the title compound: (0.21 g, 0.57 mmol). MS (ESI) m/z (M+H+): 370.9/368.8.

후처리

  1. temperaturewas heated
  2. temperatureto reflux overnight
  3. customThe volatiles were removed in vacuo
  4. customthe compound was purified by silica gel chromatography
  5. washeluting with 2% methanol with dichloromethane

출처 및 근거

ORD 기록
ord-1dc88497cf854c18aed5c14a1643c623
출처 데이터셋
uspto-grants-2012_07
특허 번호
US08211927B2

반응 노트

불러오는 중…