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Hydrogen chloride-ethyl acetate → 6-{[(1-{2-[7-(methyloxy)-2-oxo-1,5-naphthyridin-1(2H)-yl]ethyl}-4-piperidinyl)amino]methyl}-2H-pyrido[3,2-b][1,4]oxazin-3(4H)-one Hydrochloride

HRID 1510764
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HRID 1510764 반응식
[O:1]=[C:2]1[CH2:7][O:6][C:5]2[CH:8]=[CH:9][C:10]([CH2:12][NH:13][CH:14]3[CH2:19][CH2:18][N:17]([CH2:20][CH2:21][N:22]4[C:31]5[C:26](=[N:27][CH:28]=[C:29]([O:32][CH3:33])[CH:30]=5)[CH:25]=[CH:24][C:23]4=[O:34])[CH2:16][CH2:15]3)=[N:11][C:4]=2[NH:3]1.[ClH:35].C(OCC)(=O)C>C(OCC)(=O)C.CO>[ClH:35].[O:1]=[C:2]1[CH2:7][O:6][C:5]2[CH:8]=[CH:9][C:10]([CH2:12][NH:13][CH:14]3[CH2:15][CH2:16][N:17]([CH2:20][CH2:21][N:22]4[C:31]5[C:26](=[N:27][CH:28]=[C:29]([O:32][CH3:33])[CH:30]=5)[CH:25]=[CH:24][C:23]4=[O:34])[CH2:18][CH2:19]3)=[N:11][C:4]=2[NH:3]1
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

5

반응물 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 250320771-(2-(4-((3-oxo-3,4-dihydro-2H-pyrido(3,2-b)(1,4)oxazin-6-yl)methylamino)piperidin-1-yl)ethyl)-7-methoxy-1,5-naphthyridin-2(1H)-one

생성물 1

HCID 689241086-{[(1-{2-[7-(methyloxy)-2-oxo-1,5-naphthyridin-1(2H)-yl]ethyl}-4-piperidinyl)amino]methyl}-2H-pyrido[3,2-b][1,4]oxazin-3(4H)-one Hydrochloride

시약·촉매·용매 2

HCID 887Methanol용매
HCID 8857
Ethyl Acetate
용매

실험 절차

To a solution of 260 mg of 1-(2-(4-((3-oxo-3,4-dihydro-2H-pyrido(3,2-b)(1,4)oxazin-6-yl)methylamino)piperidin-1-yl)ethyl)-7-methoxy-1,5-naphthyridin-2(1H)-one in 4 mL of ethyl acetate and 2 mL of methanol, 3 mL of 4 mol/L hydrogen chloride/ethyl acetate was added, and the mixture was stirred at room temperature for 12 minutes. The solvent was distilled off under reduced pressure, thereto was added diethyl ether, and the solid was filtered off to obtain 304 mg of 1-(2-(4-((3-oxo-3,4-dihydro-2H-pyrido(3,2-b) (1,4)oxazin-6-yl)methylamino)piperidin-1-yl)ethyl)-7-methoxy-1,5-naphthyridin-2(1H)-one hydrochloride as a white solid.

후처리

  1. distillationThe solvent was distilled off under reduced pressure
  2. additionwas added diethyl ether
  3. filtrationthe solid was filtered off

출처 및 근거

ORD 기록
ord-aec2f45b31834bc89ce5b02c131b8db5
출처 데이터셋
uspto-grants-2012_07
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US08211908B2

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