Sulfuric Acid → 4-((6-Phenyl-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)methoxy)quinoline-7-carboxamide
반응식
[C:1]1([C:7]2[CH:8]=[CH:9][C:10]3[N:11]([C:13]([CH2:16][O:17][C:18]4[C:27]5[C:22](=[CH:23][C:24]([C:28]#[N:29])=[CH:25][CH:26]=5)[N:21]=[CH:20][CH:19]=4)=[N:14][N:15]=3)[N:12]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.S(=O)(=O)(O)[OH:31]>>[C:1]1([C:7]2[CH:8]=[CH:9][C:10]3[N:11]([C:13]([CH2:16][O:17][C:18]4[C:27]5[C:22](=[CH:23][C:24]([C:28]([NH2:29])=[O:31])=[CH:25][CH:26]=5)[N:21]=[CH:20][CH:19]=4)=[N:14][N:15]=3)[N:12]=2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1참가 물질
3
반응 조건
- 온도
- 90 °C
실험 절차
A mixture of 4-((6-phenyl-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)methoxy)quinoline-7-carbonitrile (0.300 g, 0.793 mmol) and SULFURIC ACID (3.00 ml, 56.3 mmol) was heated at 90° C. for 30 min. Quenched onto ice and sodium bicarbonate. Isolated solid by filtration and purified on RPHPLC. Fractions containing product were treated with 9% sodium carbonate. Removed volatiles. Product crashed out and was isolated by filtraton. MS m/z=397.1 [M+1]+. Calc'd for C22H16N6O2: 396.4.