Hydrazine → 3-Hydrazinyl-4-methyl-6-phenylpyridazine

반응식

Cl[C:2]1[N:3]=[N:4][C:5]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)=[CH:6][C:7]=1[CH3:8].[NH2:15][NH2:16]>>[CH3:8][C:7]1[CH:6]=[C:5]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)[N:4]=[N:3][C:2]=1[NH:15][NH2:16]

참가 물질

반응물 2

HCID 9321Hydrazine

HCID 1199993-Chloro-4-methyl-6-phenylpyridazine

생성물 1

HCID 30313733-Hydrazinyl-4-methyl-6-phenylpyridazine

반응 조건

온도: 100 °C

실험 절차

3-Chloro-4-methyl-6-phenylpyridazine (0.510 g, 2.49 mmol) was dissolved in hydrazine (1.56 ml, 49.8 mmol) then the reaction mixture was heated at 100° C. for 1.5 hours. The precipitate that had formed in the mixture was collected and washed with iPrOH. The solid was dried under high vacuum to afford 1-(4-methyl-6-phenylpyridazin-3-yl)hydrazine as a pale yellow solid.

후처리

customThe precipitate that had formed in the mixture
customwas collected
washwashed with iPrOH
customThe solid was dried under high vacuum

출처 및 근거

ORD 기록: ord-626bd2b5981847049f721ee0b4974d61
출처 데이터셋: uspto-grants-2012_07
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08212041B2

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