2-Hydroxy-3''-nitro-biphenyl-3-carboxylic acid → 3-(3-Amino-2-hydroxyphenyl)benzoic acid
반응식
[OH:1][C:2]1[C:7]([N+:8]([O-])=O)=[CH:6][CH:5]=[CH:4][C:3]=1[C:11]1[CH:16]=[CH:15][CH:14]=[C:13]([C:17]([OH:19])=[O:18])[CH:12]=1>CO.[Pd]>[NH2:8][C:7]1[C:2]([OH:1])=[C:3]([C:11]2[CH:16]=[CH:15][CH:14]=[C:13]([C:17]([OH:19])=[O:18])[CH:12]=2)[CH:4]=[CH:5][CH:6]=1참가 물질
4
실험 절차
A solution of 2′-hydroxy-3′-nitrobiphenyl-3-carboxylic acid (800 g, 3.2 mol) in methanol (5 L) was hydrogenated over 5% Pd/C (160 g) at room temperature for 8 hours. The reaction mixture was filtered, concentrated and slurried in THF (2.5 L) to give 3′-amino-2′-hydroxybiphenyl-3-carboxylic acid (690 g, 50.5%) as a brown solid. PXRD analysis provided the diffractogram as shown in FIG. 32.
후처리
- filtrationThe reaction mixture was filtered
- concentrationconcentrated
출처 및 근거
- ORD 기록
- ord-d05ec8b3f65a4fa89246f3a21d28fc09
- 출처 데이터셋
- uspto-grants-2012_07
- 특허 번호
- US08217021B2
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