1-Bromo 4-fluoronaphthalene → 7-(4-Bromonaphthalen-1-yloxy)-5-methyl-4,5,6,7-tetrahydrothieno[3,2-c]pyridine

HRID 1511621노트

반응식

HRID 1511621 반응식
[CH3:1][N:2]1[CH2:7][CH:6]([OH:8])[C:5]2[S:9][CH:10]=[CH:11][C:4]=2[CH2:3]1.[Br:12][C:13]1[C:22]2[C:17](=[CH:18][CH:19]=[CH:20][CH:21]=2)[C:16](F)=[CH:15][CH:14]=1>>[Br:12][C:13]1[C:22]2[C:17](=[CH:18][CH:19]=[CH:20][CH:21]=2)[C:16]([O:8][CH:6]2[CH2:7][N:2]([CH3:1])[CH2:3][C:4]3[CH:11]=[CH:10][S:9][C:5]2=3)=[CH:15][CH:14]=1

참가 물질

3

반응물 2

HCID 676471-Bromo 4-fluoronaphthaleneHCID 203668405-Methyl-4,5,6,7-tetrahydrothieno[3,2-c]pyridin-7-ol

생성물 1

HCID 684124947-(4-Bromonaphthalen-1-yloxy)-5-methyl-4,5,6,7-tetrahydrothieno[3,2-c]pyridine

실험 절차

The same method as in Example 1 was conducted using 5-methyl-4,5,6,7-tetrahydrothieno[3,2-c]pyridin-7-ol (Reference Example 14) instead of 6-methyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridin-4-ol (Reference Example 6) and was conducted using 1-bromo-4-fluoronaphthalene instead of 1-fluoronaphthalene to give the objective compound.

후처리

  1. customto give the objective compound

출처 및 근거

ORD 기록
ord-f042b2fb179446fd8169f51f630559fa
출처 데이터셋
uspto-grants-2012_07
특허 번호
US08217031B2

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