1,2-Dichloro-4-fluorobenzene → 4-(3,4-Dichlorophenyloxy)-4,5,6,7-tetrahydrothieno[2,3-c]pyridine

HRID 1511635

반응식

HRID 1511635 반응식
[S:1]1[C:5]2[CH2:6][NH:7][CH2:8][CH:9]([OH:10])[C:4]=2[CH:3]=[CH:2]1.[Cl:11][C:12]1[CH:13]=[C:14](F)[CH:15]=[CH:16][C:17]=1[Cl:18]>>[Cl:11][C:12]1[CH:13]=[C:14]([O:10][CH:9]2[CH2:8][NH:7][CH2:6][C:5]3[S:1][CH:2]=[CH:3][C:4]2=3)[CH:15]=[CH:16][C:17]=1[Cl:18]

참가 물질

3

반응물 2

HCID 740281,2-Dichloro-4-fluorobenzeneHCID 123370234,5,6,7-Tetrahydrothieno[2,3-c]pyridin-4-ol

생성물 1

HCID 684132074-(3,4-Dichlorophenyloxy)-4,5,6,7-tetrahydrothieno[2,3-c]pyridine

실험 절차

The same method as in Example 1 was conducted using 4,5,6,7-tetrahydrothieno[2,3-c]pyridin-4-ol (Reference Example 5) instead of 6-methyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridin-4-ol (Reference Example 6) and was conducted using 3,4-dichloro-1-fluorobenzene instead of 1-fluoronaphthalene to give the objective compound.

후처리

  1. customto give the objective compound

출처 및 근거

ORD 기록
ord-d06b5ce26b134463806893cb1732c61b
출처 데이터셋
uspto-grants-2012_07
특허 번호
US08217031B2

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