1-Bromo 4-fluoronaphthalene → 4-(4-Bromonaphthalen-1-yloxy)-4,5,6,7-tetrahydrothieno[2,3-c]pyridine

HRID 1511636노트

반응식

HRID 1511636 반응식
[S:1]1[C:5]2[CH2:6][NH:7][CH2:8][CH:9]([OH:10])[C:4]=2[CH:3]=[CH:2]1.[Br:11][C:12]1[C:21]2[C:16](=[CH:17][CH:18]=[CH:19][CH:20]=2)[C:15](F)=[CH:14][CH:13]=1>>[Br:11][C:12]1[C:21]2[C:16](=[CH:17][CH:18]=[CH:19][CH:20]=2)[C:15]([O:10][CH:9]2[CH2:8][NH:7][CH2:6][C:5]3[S:1][CH:2]=[CH:3][C:4]2=3)=[CH:14][CH:13]=1

참가 물질

3

반응물 2

HCID 676471-Bromo 4-fluoronaphthaleneHCID 123370234,5,6,7-Tetrahydrothieno[2,3-c]pyridin-4-ol

생성물 1

HCID 684105174-(4-Bromonaphthalen-1-yloxy)-4,5,6,7-tetrahydrothieno[2,3-c]pyridine

실험 절차

The same method as in Example 1 was conducted using 4,5,6,7-tetrahydrothieno[2,3-c]pyridin-4-ol (Reference Example 5) instead of 6-methyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridin-4-ol (Reference Example 6) and was conducted using 1-bromo-4-fluoronaphthalene instead of 1-fluoronaphthalene to give the objective compound.

후처리

  1. customto give the objective compound

출처 및 근거

ORD 기록
ord-7656617c364645b483b86865d5f2dae3
출처 데이터셋
uspto-grants-2012_07
특허 번호
US08217031B2

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