Benzene, 1,2-dichloro-3-fluoro- → 4-(2,3-Dichlorophenyloxy)-7-methyl-5,6,7,8-tetrahydro-4H-thieno[2,3-c]azepine hydrochloride

반응식

[CH3:1][N:2]1[CH2:8][CH2:7][CH:6]([OH:9])[C:5]2[CH:10]=[CH:11][S:12][C:4]=2[CH2:3]1.[Cl:13][C:14]1[C:19]([Cl:20])=[CH:18][CH:17]=[CH:16][C:15]=1F>>[ClH:13].[Cl:13][C:14]1[C:19]([Cl:20])=[CH:18][CH:17]=[CH:16][C:15]=1[O:9][CH:6]1[CH2:7][CH2:8][N:2]([CH3:1])[CH2:3][C:4]2[S:12][CH:11]=[CH:10][C:5]1=2

참가 물질

반응물 2

HCID 119011Benzene, 1,2-dichloro-3-fluoro-

HCID 684111377-methyl-5,6,7,8-tetrahydro-4H-thieno[2,3-c]azepin-4-ol

생성물 1

HCID 684256944-(2,3-Dichlorophenyloxy)-7-methyl-5,6,7,8-tetrahydro-4H-thieno[2,3-c]azepine hydrochloride

실험 절차

The same method as in Example 3 was conducted using 7-methyl-5,6,7,8-tetrahydro-4H-thieno[2,3-c]azepin-4-ol (Reference Example 22) instead of 6-methyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridin-4-ol (Reference Example 6) and was conducted using 2,3-dichloro-1-fluorobenzene instead of 1,3-difluorobenzene to give the objective compound.

후처리

customto give the objective compound

출처 및 근거

ORD 기록: ord-2f33857fe6c24d4788f0e42dd34f4abe
출처 데이터셋: uspto-grants-2012_07
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08217031B2

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