1-Bromo-2-fluorobenzene → 4-(2-Bromophenyloxy)-6-ethyl-5,6,7,8-tetrahydro-4H-thieno[2,3-d]azepine

반응식

[CH2:1]([N:3]1[CH2:9][CH:8]([OH:10])[C:7]2[CH:11]=[CH:12][S:13][C:6]=2[CH2:5][CH2:4]1)[CH3:2].[Br:14][C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=1F>>[Br:14][C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=1[O:10][CH:8]1[CH2:9][N:3]([CH2:1][CH3:2])[CH2:4][CH2:5][C:6]2[S:13][CH:12]=[CH:11][C:7]1=2

참가 물질

반응물 2

HCID 612591-Bromo-2-fluorobenzene

HCID 684098766-ethyl-5,6,7,8-tetrahydro-4H-thieno[2,3-d]azepin-4-ol

생성물 1

HCID 684092954-(2-Bromophenyloxy)-6-ethyl-5,6,7,8-tetrahydro-4H-thieno[2,3-d]azepine

실험 절차

The same method as in Example 1 was conducted using 6-ethyl-5,6,7,8-tetrahydro-4H-thieno[2,3-d]azepin-4-ol (Reference Example 45) instead of 6-methyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridin-4-ol (Reference Example 6) and was conducted using 2-bromo-1-fluorobenzene instead of 1-fluoronaphthalene to give the objective compound.

후처리

customto give the objective compound

출처 및 근거

ORD 기록: ord-1a14f927124049f4b1e79b37d4d61d52
출처 데이터셋: uspto-grants-2012_07
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08217031B2

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