(1R,3S)-methyl 1-amino-3-(4-(7-methoxyhept-1-ynyl)phenyl)cyclopentanecarboxylate → (1R,3S)-methyl 1-amino-3-(4-(7-methoxyheptyl)phenyl)cyclopentanecarboxylate

HRID 1511848노트

반응식

HRID 1511848 반응식
[NH2:1][C@:2]1([C:22]([O:24][CH3:25])=[O:23])[CH2:6][CH2:5][C@H:4]([C:7]2[CH:12]=[CH:11][C:10]([C:13]#[C:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][O:20][CH3:21])=[CH:9][CH:8]=2)[CH2:3]1.[H][H]>C(O)C.[OH-].[OH-].[Pd+2]>[NH2:1][C@:2]1([C:22]([O:24][CH3:25])=[O:23])[CH2:6][CH2:5][C@H:4]([C:7]2[CH:12]=[CH:11][C:10]([CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][O:20][CH3:21])=[CH:9][CH:8]=2)[CH2:3]1

참가 물질

5

반응물 2

HCID 68936341(1R,3S)-methyl 1-amino-3-(4-(7-methoxyhept-1-ynyl)phenyl)cyclopentanecarboxylateHCID 178418361HCID 178418361, 화합물

생성물 1

HCID 57554607(1R,3S)-methyl 1-amino-3-(4-(7-methoxyheptyl)phenyl)cyclopentanecarboxylate

시약·촉매·용매 2

HCID 9942167Palladium hydroxide촉매HCID 702Ethanol용매

실험 절차

(1R,3S)-methyl 1-amino-3-(4-(7-methoxyhept-1-ynyl)phenyl)cyclopentanecarboxylate was taken up in ethanol (14.94 ml). To this was added Pearlman's Catalyst (0.052 g, 0.075 mmol) and the mixture was stirred at ambient temperature under the atmosphere of hydrogen. After about 15 hours, the reaction mixture was filtered through Celite® and the filtrate was concentrated in vacuo to yield (1R,3S)-methyl 1-amino-3-(4-(7-methoxyheptyl)phenyl)cyclopentanecarboxylate (0.48 g, 1.38 mmol) as dark green oil.

후처리

  1. filtrationthe reaction mixture was filtered through Celite®
  2. concentrationthe filtrate was concentrated in vacuo

출처 및 근거

ORD 기록
ord-da48d54787224bdb882f0fd9c600dfe1
출처 데이터셋
uspto-grants-2012_07
특허 번호
US08217027B2

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