Triethyl methanetricarboxylate → 1-(4-Fluoro-benzyl)-4-hydroxy-2-oxo-1,2-dihydro-pyrrolo[1,2-b]pyridazine-3-carboxylic acid ethyl ester

HRID 1511917노트

반응식

HRID 1511917 반응식
C(O[C:6](=[O:21])[N:7]([CH2:13][C:14]1[CH:19]=[CH:18][C:17]([F:20])=[CH:16][CH:15]=1)[N:8]1[CH:12]=[CH:11][CH:10]=[CH:9]1)(C)(C)C.[CH2:22]([O:24][C:25](=[O:37])[CH:26](C(OCC)=O)[C:27](OCC)=[O:28])[CH3:23]>>[CH2:22]([O:24][C:25]([C:26]1[C:6](=[O:21])[N:7]([CH2:13][C:14]2[CH:15]=[CH:16][C:17]([F:20])=[CH:18][CH:19]=2)[N:8]2[CH:9]=[CH:10][CH:11]=[C:12]2[C:27]=1[OH:28])=[O:37])[CH3:23]

참가 물질

3

반응물 2

HCID 80471Triethyl methanetricarboxylateHCID 67230506(4-Fluoro-benzyl)-pyrrol-1-yl-carbamic acid tert-butyl ester

생성물 1

HCID 672304121-(4-Fluoro-benzyl)-4-hydroxy-2-oxo-1,2-dihydro-pyrrolo[1,2-b]pyridazine-3-carboxylic acid ethyl ester

실험 절차

Prepared according to the thermal cyclization condition used in Example 1 step c) from (4-fluoro-benzyl)-pyrrol-1-yl-carbamic acid tert-butyl ester (1.0 eq.) and 2-ethoxycarbonyl-malonic acid diethyl ester (2.0 eq.). ESI (m/z): 331 (M+H)+.

후처리

  1. customPrepared

출처 및 근거

ORD 기록
ord-3af73a7e65364f239f0452621a31b4ff
출처 데이터셋
uspto-grants-2012_07
특허 번호
US08217043B2

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