Methyl malonyl chloride → 4-Chloro-1-[(2-methoxycarbonyl-acetyl)-pyridin-2-ylmethyl-amino]-1H-pyrrole-2-carboxylic acid methyl ester

HRID 1512000노트

반응식

HRID 1512000 반응식
[CH3:1][O:2][C:3]([C:5]1[N:6]([NH:11][CH2:12][C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][N:14]=2)[CH:7]=[C:8]([Cl:10])[CH:9]=1)=[O:4].[CH3:19][O:20][C:21](=[O:26])[CH2:22][C:23](Cl)=[O:24]>>[CH3:1][O:2][C:3]([C:5]1[N:6]([N:11]([C:23](=[O:24])[CH2:22][C:21]([O:20][CH3:19])=[O:26])[CH2:12][C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][N:14]=2)[CH:7]=[C:8]([Cl:10])[CH:9]=1)=[O:4]

참가 물질

3

반응물 2

HCID 123460Methyl malonyl chlorideHCID 672298624-chloro-1-[(pyridin-2-ylmethyl)-amino]-1H-pyrrole-2-carboxylic acid methyl ester

생성물 1

HCID 672305774-Chloro-1-[(2-methoxycarbonyl-acetyl)-pyridin-2-ylmethyl-amino]-1H-pyrrole-2-carboxylic acid methyl ester

실험 절차

Prepared according to the acylation condition used in Example 2 step f) from 4-chloro-1-[(pyridin-2-ylmethyl)-amino]-1H-pyrrole-2-carboxylic acid methyl ester and chlorocarbonyl-acetic acid methyl ester (1.5 eq.). 1H NMR (CDCl3, δ in ppm): 8.5 (m, 1H), 7.68 (m, 1H), 7.39 (m, 1H), 721 (m, 1H), 6.85 (d, 1H, J=1.6 Hz), 6.80 (d, 1H, J=1.6 Hz), 5.48 (d, 1H, J=15.4 Hz), 4.46 (d, 1H, J=15.4 Hz), 3.79 (s, 3H), 3.69 (s, 3H), 3.19 (s, 2H).

후처리

  1. customPrepared

출처 및 근거

ORD 기록
ord-eb8baeb8c11143749985cb156c646f0f
출처 데이터셋
uspto-grants-2012_07
특허 번호
US08217043B2

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