Sodium methanolate methanol → 4-(4-Fluoro-benzyl)-1-hydroxy-3-oxo-6-trifluoromethyl-3,4-dihydro-4,4a-diaza-fluorene-2-carboxylic acid methyl ester

HRID 1512007

반응식

HRID 1512007 반응식
C([O:3][C:4]([C:6]1[N:7]([N:19]([C:28](=[O:35])[CH2:29][C:30]([O:32][CH2:33]C)=[O:31])[CH2:20][C:21]2[CH:26]=[CH:25][C:24]([F:27])=[CH:23][CH:22]=2)[C:8]2[C:13]([CH:14]=1)=[CH:12][CH:11]=[C:10]([C:15]([F:18])([F:17])[F:16])[CH:9]=2)=O)C.C[O-].[Na+].CO>>[CH3:33][O:32][C:30]([C:29]1[C:28](=[O:35])[N:19]([CH2:20][C:21]2[CH:26]=[CH:25][C:24]([F:27])=[CH:23][CH:22]=2)[N:7]2[C:6](=[CH:14][C:13]3[C:8]2=[CH:9][C:10]([C:15]([F:18])([F:17])[F:16])=[CH:11][CH:12]=3)[C:4]=1[OH:3])=[O:31]

참가 물질

3

반응물 2

HCID 23694274Sodium methanolate methanolHCID 672304801-[(2-Ethoxycarbonyl-acetyl)-(4-fluoro-benzyl)-amino]-6-trifluoromethyl-1H-indole-2-carboxylic acid ethyl ester

생성물 1

HCID 687624054-(4-Fluoro-benzyl)-1-hydroxy-3-oxo-6-trifluoromethyl-3,4-dihydro-4,4a-diaza-fluorene-2-carboxylic acid methyl ester수율 22.3%

실험 절차

A mixture of 1-[(2-ethoxycarbonyl-acetyl)-(4-fluoro-benzyl)-amino]-6-trifluoromethyl-1H-indole-2-carboxylic acid ethyl ester (160 mg, 0.32 mmol) in 0.5 N NaOMe/MeOH solution (2.5 mL, 1.25 mmol) was refluxed overnight. After cooled, the mixture was concentrated, and the residue was dissolved in water (80 mL), acidified to pH=3-4 using 1 N HCl solution, extracted with EtOAc (2 times). Combined organic layers were washed with brine, dried over MgSO4, filtered and concentrated. Crude product was purified by silica gel chromatography (50%-100% EtOAc/DCM then 2%-10% MeOH/DCM) to provide the title compound 31 mg. ESI (m/z): 435.14 (M+H)+.

후처리

  1. temperaturewas refluxed overnight
  2. temperatureAfter cooled
  3. concentrationthe mixture was concentrated
  4. dissolutionthe residue was dissolved in water (80 mL)
  5. extractionextracted with EtOAc (2 times)
  6. washCombined organic layers were washed with brine
  7. dry with materialdried over MgSO4
  8. filtrationfiltered
  9. concentrationconcentrated
  10. customCrude product was purified by silica gel chromatography (50%-100% EtOAc/DCM

출처 및 근거

ORD 기록
ord-03b56b5388634c7a80d6d801f4e57349
출처 데이터셋
uspto-grants-2012_07
특허 번호
US08217043B2

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