p-Toluenesulfonate → (S)-2-Methyl-[1,4]bipiperidinyl

HRID 1512047노트

반응식

HRID 1512047 반응식
Cl.Cl.C[C@H]1CCCN1[C@@H]1CCNC1.[C:14]([C@:21]1(C)[CH2:26][CH2:25][CH2:24][CH2:23][N:22]1[CH:27]1[CH2:32][CH2:31][NH:30][CH2:29][CH2:28]1)(OC(C)(C)C)=O.S(C1C=CC(C)=CC=1)([O-])(=O)=O>>[CH3:14][C@H:21]1[CH2:26][CH2:25][CH2:24][CH2:23][N:22]1[CH:27]1[CH2:32][CH2:31][NH:30][CH2:29][CH2:28]1

참가 물질

4

반응물 3

HCID 85570p-ToluenesulfonateHCID 67423613(2S,3'R)-2-Methyl-[1,3']bipyrrolidinyl dihydrochlorideHCID 67423644BOC-(S)-2-Methyl-[1,4]bipiperidinyl

생성물 1

HCID 28213026(S)-2-Methyl-[1,4]bipiperidinyl수율 94%

실험 절차

The title compound was prepared in a manner substantially the same as intermediate (2S,3′R)-2-Methyl-[1,3′]bipyrrolidinyl dihydrochloride by acid hydrolysis of BOC-(S)-2-Methyl-[1,4′]bipiperidinyl which was synthesized by condensation of corresponding tosylate with (S)-(−)-2-methylpiperindine to get 1.37 g (94% yield) of the title product as a clear oil.

출처 및 근거

ORD 기록
ord-ca5c22ced8ae4f38bfb622a692fc23be
출처 데이터셋
uspto-grants-2012_07
특허 번호
US08217052B2

반응 노트

불러오는 중…