Oxalyl chloride → 3-Cyclohexylprop-2-enoyl chloride

HRID 1512183

반응식

HRID 1512183 반응식
[CH:1]1([CH:7]=[CH:8][C:9]([OH:11])=O)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.C(Cl)(=O)C([Cl:15])=O>C(Cl)Cl.CN(C)C=O>[CH:1]1([CH:7]=[CH:8][C:9]([Cl:15])=[O:11])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

참가 물질

5

반응물 2

HCID 65578Oxalyl chlorideHCID 2873483-Cyclohexylacrylic acid

생성물 1

HCID 566232073-Cyclohexylprop-2-enoyl chloride

시약·촉매·용매 2

HCID 6228Dimethylformamide촉매HCID 6344Dichloromethane용매

실험 절차

A solution of 3-cyclohexyl-acrylic acid (5.0 g, 32.5 mmol) and oxalyl chloride (3.4 ml, 34.0 mmol) in anhydrous DCM (50 ml) was treated with one drop of dimethylformamide. The resulting solution was stirred at room temperature for 18 h, concentrated and used directly in the next step.

후처리

  1. concentrationconcentrated

출처 및 근거

ORD 기록
ord-809844e652754a09a33b33c3a53ace32
출처 데이터셋
uspto-grants-2012_07
특허 번호
US08217060B2

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