Tetrabutylammonium Fluoride → HCID 68591664, 화합물
반응식
[F-].C([N+](CCCC)(CCCC)CCCC)CCC.CC([Si](C1C=CC=CC=1)(C1C=CC=CC=1)[O:24][C:25]1[CH:26]=[C:27]2[C:32](=[CH:33][CH:34]=1)[C:31]([C:35]([NH:37][C:38]1[CH:43]=[C:42]([C:44]([F:47])([F:46])[F:45])[CH:41]=[C:40]([N:48]3[CH:52]=[C:51]([CH3:53])[N:50]=[CH:49]3)[CH:39]=1)=[O:36])=[CH:30][CH:29]=[CH:28]2)(C)C>O1CCCC1>[OH:24][C:25]1[CH:26]=[C:27]2[C:32](=[CH:33][CH:34]=1)[C:31]([C:35]([NH:37][C:38]1[CH:43]=[C:42]([C:44]([F:45])([F:46])[F:47])[CH:41]=[C:40]([N:48]3[CH:52]=[C:51]([CH3:53])[N:50]=[CH:49]3)[CH:39]=1)=[O:36])=[CH:30][CH:29]=[CH:28]2참가 물질
4
실험 절차
A solution of tetrabutylammonium fluoride (3.5 mL of 1 M) in tetrahydrofuran is added to a stirred solution of 6[[(1,1-dimethylethyl)diphenylsilyl]oxy]-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl]-1-naphthalenecarboxamide (1.91 g, 2.94 mmol) in tetrahydrofuran (50 mL) and the mixture is stirred at room temperature for 60 min. The solvent is evaporated off under reduced pressure and the residue is purified by column chromatography (SiO2; ethyl acetate) to afford the title compound as a cream solid m.p.: 169-172° C.