Lithium borohydride → [5-(4-Bromo-phenyl)-3-methyl-isoxazol-4-yl]-methanol
반응식
C[O:2][C:3]([C:5]1[C:6]([CH3:17])=[N:7][O:8][C:9]=1[C:10]1[CH:15]=[CH:14][C:13]([Br:16])=[CH:12][CH:11]=1)=O.[BH4-].[Li+]>CCO>[Br:16][C:13]1[CH:12]=[CH:11][C:10]([C:9]2[O:8][N:7]=[C:6]([CH3:17])[C:5]=2[CH2:3][OH:2])=[CH:15][CH:14]=1참가 물질
4
반응 조건
- 온도
- 60 °C
실험 절차
5-(4-Bromo-phenyl)-3-methyl-isoxazole-4-carboxylic acid methyl ester (5 g, 16.8 mmol) and lithium borohydride (1.85 g, 84.1 mmol) were combined in EtOH and stirred at 60° C. After aqueous workup, the crude material was purified by silica gel chromatography to give the title compound.
후처리
- customAfter aqueous workup, the crude material was purified by silica gel chromatography
출처 및 근거
- ORD 기록
- ord-94eefd45ccdb420d836a1638f1c257e4
- 출처 데이터셋
- uspto-grants-2012_07
- 특허 번호
- US08217066B2
반응 노트
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