Potassium Cyanide → [5-(4-Bromo-phenyl)-3-methyl-isoxazol-4-yl]acetonitrile

HRID 1512568노트

반응식

HRID 1512568 반응식
Br[CH2:2][C:3]1[C:4]([CH3:15])=[N:5][O:6][C:7]=1[C:8]1[CH:13]=[CH:12][C:11]([Br:14])=[CH:10][CH:9]=1.[C-:16]#[N:17].[K+]>CN(C=O)C>[Br:14][C:11]1[CH:12]=[CH:13][C:8]([C:7]2[O:6][N:5]=[C:4]([CH3:15])[C:3]=2[CH2:2][C:16]#[N:17])=[CH:9][CH:10]=1

참가 물질

4

반응물 2

HCID 9032Potassium CyanideHCID 665772234-Bromomethyl-5-(4-bromo-phenyl)-3-methyl-isoxazole

생성물 1

HCID 66577425[5-(4-Bromo-phenyl)-3-methyl-isoxazol-4-yl]acetonitrile

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

반응 조건

온도
65 °C

실험 절차

To 4-bromomethyl-5-(4-bromo-phenyl)-3-methyl-isoxazole (10.74 mmol) in DMF (30 mL) was added potassium cyanide (0.729 g, 10.74 mmol) and the reaction stirred at 65° C. overnight. After aqueous workup, the crude material was purified by silica gel chromatography (0-70% EtOAc in hexanes) to give the title compound.

후처리

  1. customAfter aqueous workup, the crude material was purified by silica gel chromatography (0-70% EtOAc in hexanes)

출처 및 근거

ORD 기록
ord-11671ad5153a4e4686ffb875199dd1e8
출처 데이터셋
uspto-grants-2012_07
특허 번호
US08217066B2

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