Sodium Iodide → HCID 66577474, 화합물

HRID 1512640노트

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HRID 1512640 반응식
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[O:12][N:11]=[C:10]([CH3:13])[C:9]=2[CH:14]=[O:15])=[CH:4][CH:3]=1.Br[C:17]([F:21])([F:20])[CH:18]=[CH2:19].[In].[I-].[Na+]>CN(C=O)C>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[O:12][N:11]=[C:10]([CH3:13])[C:9]=2[CH:14]([OH:15])[C:17]([F:21])([F:20])[CH:18]=[CH2:19])=[CH:6][CH:7]=1

참가 물질

6

반응물 4

HCID 5238Sodium IodideHCID 5550853-bromo-3,3-difluoroprop-1-eneHCID 5359967IndiumHCID 821337925-(4-Bromo-phenyl)-3-methyl-isoxazole-4-carbaldehyde

생성물 1

HCID 66577474HCID 66577474, 화합물

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

5-(4-Bromo-phenyl)-3-methyl-isoxazole-4-carbaldehyde (0.511 g, 1.92 mmol), 3-bromo-3,3-difluoro-propene (0.4977 g, 3.07 mmol), indium (0.357 g, 3.07 mmol) and sodium iodide (0.0142 g, 0.096 mmol) were combined in DMF (5 mL) and stirred at room temperature overnight. The reaction mixture was submitted to standard aqueous workup to afford the title compound, which was taken to the next step without further purification.

출처 및 근거

ORD 기록
ord-e6a8ad9c6ca8477a9e786cabf7114cf0
출처 데이터셋
uspto-grants-2012_07
특허 번호
US08217066B2

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