Ethyl (2E)-3-(5-cyano-1H-indol-2-yl)-2-propenoate → ethyl 3-(5-cyano-1H-indol-2-yl)propanoate

HRID 1512744노트

반응식

HRID 1512744 반응식
[C:1]([C:3]1[CH:4]=[C:5]2[C:9](=[CH:10][CH:11]=1)[NH:8][C:7](/[CH:12]=[CH:13]/[C:14]([O:16][CH2:17][CH3:18])=[O:15])=[CH:6]2)#[N:2]>CO.CCOC(C)=O.[Pd]>[C:1]([C:3]1[CH:4]=[C:5]2[C:9](=[CH:10][CH:11]=1)[NH:8][C:7]([CH2:12][CH2:13][C:14]([O:16][CH2:17][CH3:18])=[O:15])=[CH:6]2)#[N:2]

참가 물질

5

반응물 1

HCID 67025185Ethyl (2E)-3-(5-cyano-1H-indol-2-yl)-2-propenoate

생성물 1

HCID 67025284ethyl 3-(5-cyano-1H-indol-2-yl)propanoate수율 99.2%

시약·촉매·용매 3

HCID 23938Palladium촉매HCID 887Methanol용매HCID 8857Ethyl Acetate용매

실험 절차

Ethyl (2E)-3-(5-cyano-1H-indol-2-yl)-2-propenoate (D29) (200 mg) in methanol (40 mL) and EtOAc (20 mL) was hydrogenated using the H-cube (full mode) with a large 10% Pd—C catcart (flow rate: 2.5 mL/min). The solvent was evaporated to afford ethyl 3-(5-cyano-1H-indol-2-yl)propanoate (D30) (200 mg) as a white solid. MS (ES): C14H14N2O2 requires 242; found 243.2 (M+H+).

후처리

  1. customThe solvent was evaporated

출처 및 근거

ORD 기록
ord-6a9ddd9792ca4676825528d1ad0fc610
출처 데이터셋
uspto-grants-2012_07
특허 번호
US08217028B2

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