Water → 2-(Chloromethyl)-3,4-difluoro-1-methoxybenzene

HRID 1512967노트

반응식

HRID 1512967 반응식
[F:1][C:2]1[C:9]([F:10])=[CH:8][CH:7]=[C:6]([O:11][CH3:12])[C:3]=1[CH2:4]O.S(Cl)([Cl:15])=O.O>C1(C)C=CC=CC=1>[F:1][C:2]1[C:9]([F:10])=[CH:8][CH:7]=[C:6]([O:11][CH3:12])[C:3]=1[CH2:4][Cl:15]

참가 물질

5

반응물 3

HCID 962WaterHCID 24386Thionyl ChlorideHCID 38708672,3-Difluoro-6-methoxybenzyl alcohol

생성물 1

HCID 593096112-(Chloromethyl)-3,4-difluoro-1-methoxybenzene

시약·촉매·용매 1

HCID 1140Toluene용매

실험 절차

To a solution of 2,3-difluoro-6-methoxybenzyl alcohol (6.97 g) in toluene (100 mL) was added thionyl chloride (4.4 mL) in a dropwise manner at room temperature, and the mixture was stirred at room temperature for 1 hour. The reaction mixture was poured into water, and the resulting mixture was extracted with ethyl acetate. The extract was washed with water and brine twice, and dried over anhydrous sodium sulfate. The solvent was removed under reduced pressure to give the title compound (7.65 g).

후처리

  1. extractionthe resulting mixture was extracted with ethyl acetate
  2. washThe extract was washed with water and brine twice
  3. dry with materialdried over anhydrous sodium sulfate
  4. customThe solvent was removed under reduced pressure

출처 및 근거

ORD 기록
ord-c7ea50b9d7aa45b38bc8f6f1ea5d9a4e
출처 데이터셋
uspto-grants-2012_07
특허 번호
US08217069B2

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