Thionyl Chloride → 4-Acetyl-1-naphthalenecarbonyl chloride
반응식
S(Cl)([Cl:3])=O.[C:5]([C:8]1[C:17]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)[C:11]([C:18]([OH:20])=O)=[CH:10][CH:9]=1)(=[O:7])[CH3:6]>C1(C)C=CC=CC=1>[C:5]([C:8]1[C:17]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)[C:11]([C:18]([Cl:3])=[O:20])=[CH:10][CH:9]=1)(=[O:7])[CH3:6]참가 물질
4
반응 조건
- 온도
- 90 °C
실험 절차
Thionyl chloride (35.00 g, 0.29 mol) was added to 4-acetyl-1-naphthalenecarboxylic acid (51.70 g, 0.24 mol) in toluene (350 mL). The mixture was warmed to 90° C. for 8.5 h. After cooling to 25° C., the solvent was removed under reduced pressure to give the title product as an off-white solid (55.1 g, 98.7% yield).
후처리
- temperatureAfter cooling to 25° C.
- customthe solvent was removed under reduced pressure
출처 및 근거
- ORD 기록
- ord-a3d0b757d72c48aca0dfd6b973ff24cb
- 출처 데이터셋
- uspto-grants-2012_07
- 특허 번호
- US08217180B2
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