4-Fluorophenyl isocyanate → HCID 44514201, 화합물

반응식

[N:1]1([C:7]2[N:12]=[C:11]([N:13]3[CH2:18][CH2:17][O:16][CH2:15][CH2:14]3)[N:10]=[C:9]([C:19]3[CH:25]=[CH:24][C:22]([NH2:23])=[CH:21][CH:20]=3)[N:8]=2)[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.[F:26][C:27]1[CH:32]=[CH:31][C:30]([N:33]=[C:34]=[O:35])=[CH:29][CH:28]=1>>[N:1]1([C:7]2[N:12]=[C:11]([N:13]3[CH2:18][CH2:17][O:16][CH2:15][CH2:14]3)[N:10]=[C:9]([C:19]3[CH:25]=[CH:24][C:22]([NH:23][C:34]([NH:33][C:30]4[CH:31]=[CH:32][C:27]([F:26])=[CH:28][CH:29]=4)=[O:35])=[CH:21][CH:20]=3)[N:8]=2)[CH2:2][CH2:3][O:4][CH2:5][CH2:6]1

참가 물질

반응물 2

HCID 709554-Fluorophenyl isocyanate

HCID 453790874-(4,6-Dimorpholino-1,3,5-triazin-2-yl)aniline

생성물 1

HCID 44514201HCID 44514201, 화합물수율 33.9%

실험 절차

Starting from 4-(4,6-dimorpholin-4-yl-1,3,5-triazin-2-yl)aniline (0.140 g 0.40 mmoles) and 4-fluorophenyl isocyanate (83 mg, 0.61 mmole), 65 mg (33% yield) of the title product was isolated as white solid. (M+H)=480.3

출처 및 근거

ORD 기록: ord-cacd4125426744269bdeabb8f2c76ed0
출처 데이터셋: uspto-grants-2012_07
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08217036B2

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