Potassium Carbonate → HCID 57860590, 화합물

반응식

[CH2:1]([C:3]1[N:8]([CH2:9][C:10](=[O:17])[C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[C:7](=[O:18])[C:6]2[C:19]([O:28][CH:29]([CH3:31])[CH3:30])=[C:20]([C:23]([O:25][CH2:26][CH3:27])=[O:24])[N:21]([CH3:22])[C:5]=2[CH:4]=1)[CH3:2].C(=O)([O-])[O-].[K+].[K+].S(OC(C)C)(OC(C)C)(=O)=O>>[CH2:1]([C:3]1[N:8]([CH2:9][C:10](=[O:17])[C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[C:7](=[O:18])[C:6]2[C:19]([O:28][CH:29]([CH3:30])[CH3:31])=[C:20]([C:23]([OH:25])=[O:24])[N:21]([CH3:22])[C:5]=2[CH:4]=1)[CH3:2].[CH2:1]([C:3]1[N:8]([CH2:9][C:10](=[O:17])[C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[C:7](=[O:18])[C:6]2[C:19]([O:28][CH:29]([CH3:31])[CH3:30])=[C:20]([C:23]([O:25][CH2:26][CH3:27])=[O:24])[N:21]([CH3:22])[C:5]=2[CH:4]=1)[CH3:2]

참가 물질

반응물 3

HCID 11430Potassium Carbonate

HCID 18096Diisopropyl sulfate

HCID 66893015HCID 66893015, 화합물

생성물 2

HCID 57860590HCID 57860590, 화합물수율 97%

HCID 66893015HCID 66893015, 화합물

실험 절차

In the same manner as in Reference Example 56, ethyl 6-ethyl-1-methyl-3-(1-methylethoxy)-4-oxo-5-(2-oxo-2-phenylethyl)-4,5-dihydro-1H-pyrrolo[3,2-c]pyridine-2-carboxylate (291 mg, 46%) was obtained as a pale-purple powder from the compound of Reference Example 40 (574 mg, 1.50 mmol), potassium carbonate (1.04 g, 7.5 mmol) and diisopropyl sulfate (1.37 g, 7.5 mmol). The title compound (242 mg, 97%) was obtained as a colorless powder from the thus-obtained ethyl 6-ethyl-1-methyl-3-(1-methylethoxy)-4-oxo-5-(2-oxo-2-phenylethyl)-4,5-dihydro-1H-pyrrolo[3,2-c]pyridine-2-carboxylate (267 mg, 0.63 mmol) by a method similar to that in Reference Example 59.