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[F:1][C:2]1[CH:3]=[N:4][C:5]2[CH:6]=[C:7]([F:16])[C:8](=[O:15])[N:9]3CC(=C)C=1[C:10]=23.S([O-])([O-])=O.[Na+].[Na+].[C:23]([OH:27])([CH3:26])([CH3:25])[CH3:24].[OH2:28]>>[F:1][C:2]1[CH:3]=[N:4][C:5]2[CH:6]=[C:7]([F:16])[C:8](=[O:15])[N:9]3[CH2:25][C:23]([OH:27])([CH2:26][OH:28])[C:24]=1[C:10]=23참가 물질
4
실험 절차
A solution of 3,8-difluoro-4-methylidene-4,5-dihydro-7H-pyrrolo[3,2,1-de]-1,5-naphthyridin-7-one (631 mg, 2.9 mmol) in tert-butanol/water (30 ml/30 ml) was treated with AD mix alpha (4.3 g) under argon. After 18 hours stirring the reaction mixture was treated with saturated sodium sulphite solution (30 ml). After 10 minutes stirring the mixture was extracted with 20% methanol in dichloromethane (3×300 ml). The organic extracts were dried over magnesium sulphate and evaporated affording a white solid (710 mg, 97%).
후처리
- additionmix alpha (4.3 g) under argon
- stirringAfter 10 minutes stirring the mixture
- extractionwas extracted with 20% methanol in dichloromethane (3×300 ml)
- dry with materialThe organic extracts were dried over magnesium sulphate
- customevaporated
출처 및 근거
- ORD 기록
- ord-c9aded2d0f824bf9b94d7c7d4dcc8f67
- 출처 데이터셋
- uspto-grants-2010_06
- 특허 번호
- US07732460B2
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