Formic Acid → N-(4-chlorophenyl)formamide

HRID 1514357

반응식

HRID 1514357 반응식
[Cl:1][C:2]1[CH:8]=[CH:7][C:5]([NH2:6])=[CH:4][CH:3]=1.[CH:9](O)=[O:10]>>[Cl:1][C:2]1[CH:8]=[CH:7][C:5]([NH:6][CH:9]=[O:10])=[CH:4][CH:3]=1

참가 물질

3

반응물 2

HCID 284Formic AcidHCID 78124-Chloroaniline

생성물 1

HCID 17475N-(4-chlorophenyl)formamide수율 88%

실험 절차

4-Chloroaniline (10 g, 78.4 mmol) and formic acid were heated to reflux for 30 minutes. The reaction mixture was concentrated in vacuo. Water was added and basified with sodium carbonate and extracted with ethyl acetate. The combined organic phases were dried over magnesium sulphate, filtrated and evaporated to give N-(4-chloro-phenyl)-formamide (10.7 g, 88%).

후처리

  1. temperatureto reflux for 30 minutes
  2. concentrationThe reaction mixture was concentrated in vacuo
  3. additionWater was added
  4. extractionextracted with ethyl acetate
  5. dry with materialThe combined organic phases were dried over magnesium sulphate
  6. filtrationfiltrated
  7. customevaporated

출처 및 근거

ORD 기록
ord-2c1aabcd1275451db6168ebd9989e894
출처 데이터셋
uspto-grants-2012_07
특허 번호
US08222262B2

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