1,4-Dioxane → HCID 178432715, 화합물

반응식

[CH3:1][C:2]1[S:3][C:4]([C:8]2[CH:13]=[CH:12][N:11]=[C:10](S(C)(=O)=O)[N:9]=2)=[C:5]([CH3:7])[N:6]=1.[O:18]1CCOCC1>>[CH3:1][C:2]1[S:3][C:4]([C:8]2[CH:13]=[CH:12][NH:11][C:10](=[O:18])[N:9]=2)=[C:5]([CH3:7])[N:6]=1

참가 물질

반응물 2

HCID 312751,4-Dioxane

HCID 58742216HCID 58742216, 화합물

생성물 1

HCID 178432715HCID 178432715, 화합물수율 75%

실험 절차

4-(2,4-dimethyl-thiazol-5-yl)-2-methanesulfonyl-pyrimidine (288 mg, 1.07 mmol) was dissolved in dioxane (13 ml) and then 2N NaOHaq (6 ml, 12 mmol) was added. After stirring at room temperature for 1 hour, the solution was acidified with 37% HClaq. The mixture was evaporated and the residue was purified by flash chromatography with DCM-MeOH (9-1) to give 166 mg of the title compound. (75% yield).

후처리

addition2N NaOHaq (6 ml, 12 mmol) was added
customThe mixture was evaporated
customthe residue was purified by flash chromatography with DCM-MeOH (9-1)

출처 및 근거

ORD 기록: ord-f04966f02b6148c6b164dce2ca69c469
출처 데이터셋: uspto-grants-2012_07
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08222266B2

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