Urea → 2(1H)-Quinazolinone, 4-phenyl-

HRID 1515178노트

반응식

HRID 1515178 반응식
[NH2:1][C:2]1[CH:15]=[CH:14][CH:13]=[CH:12][C:3]=1[C:4]([C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1)=O.[NH2:16][C:17](N)=[O:18]>C(O)(=O)C>[C:6]1([C:4]2[C:3]3[C:2](=[CH:15][CH:14]=[CH:13][CH:12]=3)[NH:1][C:17](=[O:18])[N:16]=2)[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1

참가 물질

4

반응물 2

HCID 1176UreaHCID 760802-Aminobenzophenone

생성물 1

HCID 634302(1H)-Quinazolinone, 4-phenyl-

시약·촉매·용매 1

HCID 176Acetic Acid용매

실험 절차

A solution of 2-aminobenzophenone (100 g, 0.51 mol), urea (55 g, 0.93 mol) and acetic acid (300 mL) was stirred at 110° C. for 18 h. The reaction mixture was cooled to rt and filtered. The solid was washed with water and dried under reduced pressure. 4-Phenylquinazolin-2(1H)-one was isolated as a yellow solid and was used without further purification.

후처리

  1. filtrationfiltered
  2. washThe solid was washed with water
  3. customdried under reduced pressure

출처 및 근거

ORD 기록
ord-b3e8932ddb3b4acba0febed6171f148d
출처 데이터셋
uspto-grants-2012_07
특허 번호
US08222263B2

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