Ethanol → Benzoic acid, 3-(aminosulfonyl)-4-chloro-, ethyl ester

HRID 1515411노트

반응식

HRID 1515411 반응식
[Cl:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([OH:8])=[O:7])=[CH:4][C:3]=1[S:11](=[O:14])(=[O:13])[NH2:12].[CH2:15](O)[CH3:16]>>[CH2:15]([O:7][C:6](=[O:8])[C:5]1[CH:9]=[CH:10][C:2]([Cl:1])=[C:3]([S:11](=[O:13])(=[O:14])[NH2:12])[CH:4]=1)[CH3:16]

참가 물질

3

반응물 2

HCID 702EthanolHCID 145684-Chloro-3-sulfamoylbenzoic acid

생성물 1

HCID 15938945Benzoic acid, 3-(aminosulfonyl)-4-chloro-, ethyl ester수율 99%

실험 절차

To a suspension of 4-chloro-3-sulfamoyl-benzoic acid (50 g, 212 mmol) in 500 mL ethanol is bubbled HCl gas for 10 minutes. The resulting suspension is then heated at reflux for 16 h, cooled and concentrated in vacuo. The resulting residue is recrystallized from isopronanol to yield 55.9 g (99%) of the title compound as an off-white solid.

후처리

  1. customis bubbled HCl gas for 10 minutes
  2. temperatureThe resulting suspension is then heated
  3. temperatureat reflux for 16 h
  4. temperaturecooled
  5. concentrationconcentrated in vacuo
  6. customThe resulting residue is recrystallized from isopronanol

출처 및 근거

ORD 기록
ord-a49ffe99593c4c9c9a5206b847320eb8
출처 데이터셋
uspto-grants-2012_07
특허 번호
US08222424B2

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