Potassium Carbonate → HCID 178515692, 화합물
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C([N:4]1[C:8]2=[N:9][C:10]([O:13]C(=O)C)=[CH:11][CH:12]=[C:7]2[CH:6]=[CH:5]1)(=O)C.C(=O)([O-])[O-].[K+].[K+]>CO.O>[NH:4]1[C:8]2=[N:9][C:10]([OH:13])=[CH:11][CH:12]=[C:7]2[CH:6]=[CH:5]1참가 물질
4
실험 절차
A mixture of acetic acid 1-acetyl-1H-pyrrolo[2,3-b]pyridin-6-yl ester (4.0 g, 18.3 mmol) and potassium carbonate (10.45 g, 75.7 mmol) in methanol/water (50%, 260 mL) was stirred at room temperature for 12 h. The reaction mixture was concentrated to half its volume and extracted with chloroform. The organic layer was dried over anhydrous sodium sulfate and evaporated. The residue was purified by flash column chromatography (silica gel from QingDao, 200-300 mesh, 10% methanol/dichloromethane) afforded 1H-pyrrolo[2,3-b]pyridin-6-ol (1.52 g, 62%): LC/MS m/e calcd for C7H6N2O [M+H]+ 135.14, observed 135.0.
후처리
- concentrationThe reaction mixture was concentrated to half its volume
- extractionextracted with chloroform
- dry with materialThe organic layer was dried over anhydrous sodium sulfate
- customevaporated
- customThe residue was purified by flash column chromatography (silica gel from QingDao, 200-300 mesh, 10% methanol/dichloromethane)
출처 및 근거
- ORD 기록
- ord-62dbae19759e45a593c7cdaad8ad42d7
- 출처 데이터셋
- uspto-grants-2012_07
- 특허 번호
- US08222416B2
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