Dimethylamine → Methyl 6-dimethylamino-4-(trifluoromethyl)-pyridine-3-carboxylate

HRID 1516391

반응식

HRID 1516391 반응식
Cl[C:2]1[CH:11]=[C:10]([C:12]([F:15])([F:14])[F:13])[C:5]([C:6]([O:8][CH3:9])=[O:7])=[CH:4][N:3]=1.[CH3:16][NH:17][CH3:18]>O>[CH3:16][N:17]([CH3:18])[C:2]1[N:3]=[CH:4][C:5]([C:6]([O:8][CH3:9])=[O:7])=[C:10]([C:12]([F:15])([F:14])[F:13])[CH:11]=1

참가 물질

4

반응물 2

HCID 674DimethylamineHCID 2775340Methyl 6-chloro-4-(trifluoromethyl)nicotinate

생성물 1

HCID 68933112Methyl 6-dimethylamino-4-(trifluoromethyl)-pyridine-3-carboxylate

시약·촉매·용매 1

HCID 962Water용매

반응 조건

온도
100 °C

실험 절차

A mixture of 2.5 g (10.43 mmol) of methyl 6-chloro-4-(trifluoromethyl)nicotinate and 18.4 ml (146 mmol) of a 40% solution of dimethylamine in water is heated at 100° C. for 1 hour. A precipitate is subsequently collected by filtering the cooled mixture and is washed with 150 ml of water. After drying under reduced pressure, 2.3 g of the expected compound are isolated.

후처리

  1. customA precipitate is subsequently collected
  2. filtrationby filtering the cooled mixture
  3. washis washed with 150 ml of water
  4. dry with materialAfter drying under reduced pressure, 2.3 g of the expected compound
  5. customare isolated

출처 및 근거

ORD 기록
ord-9787a9b6ee454aa89cb9e9406248b7bf
출처 데이터셋
uspto-grants-2012_07
특허 번호
US08227489B2

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