6-Methylchromone-2-carboxylic Acid → 6-Methyl-4-oxo-4H-chromene-2-carboxylic acid {2-methyl-4-[3-(2-methyl-pyrrolidin-1-ylmethyl)-pyrrolidin-1-yl]-phenyl}-amide

HRID 1516559노트

반응식

HRID 1516559 반응식
[CH3:1][C:2]1[CH:7]=[C:6]([N:8]2[CH2:12][CH2:11][CH:10]([CH2:13][N:14]3[CH2:18][CH2:17][CH2:16][CH:15]3[CH3:19])[CH2:9]2)[CH:5]=[CH:4][C:3]=1[NH2:20].[CH3:21][C:22]1[CH:23]=[C:24]2[C:29](=[CH:30][CH:31]=1)[O:28][C:27]([C:32](O)=[O:33])=[CH:26][C:25]2=[O:35]>>[CH3:1][C:2]1[CH:7]=[C:6]([N:8]2[CH2:12][CH2:11][CH:10]([CH2:13][N:14]3[CH2:18][CH2:17][CH2:16][CH:15]3[CH3:19])[CH2:9]2)[CH:5]=[CH:4][C:3]=1[NH:20][C:32]([C:27]1[O:28][C:29]2[C:24]([C:25](=[O:35])[CH:26]=1)=[CH:23][C:22]([CH3:21])=[CH:31][CH:30]=2)=[O:33]

참가 물질

3

반응물 2

HCID 6887046-Methylchromone-2-carboxylic AcidHCID 684676422-Methyl-4-[3-(2-methyl-pyrrolidin-1-ylmethyl)-pyrrolidin-1-yl]-phenylamine

생성물 1

HCID 252637186-Methyl-4-oxo-4H-chromene-2-carboxylic acid {2-methyl-4-[3-(2-methyl-pyrrolidin-1-ylmethyl)-pyrrolidin-1-yl]-phenyl}-amide

실험 절차

The title compound was prepared in a manner substantially the same as Example 1 by coupling 2-methyl-4-[3-(2-methyl-pyrrolidin-1-ylmethyl)-pyrrolidin-1-yl]-phenylamine with 6-methyl-4-oxo-4H-chromene-2-carboxylic acid. MS: 460.3 (M+H).

출처 및 근거

ORD 기록
ord-2245a29754b7424384d771d9bf43a2cc
출처 데이터셋
uspto-grants-2012_07
특허 번호
US08227504B2

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