Methylamine → 2-((4-(Aminomethyl)benzyl)oxy)pyrimidin-4-amine

HRID 1516780노트

반응식

HRID 1516780 반응식
[NH2:1][C:2]1[CH:7]=[CH:6][N:5]=[C:4]([O:8][CH2:9][C:10]2[CH:23]=[CH:22][C:13]([CH2:14][NH:15]C(=O)C(F)(F)F)=[CH:12][CH:11]=2)[N:3]=1.CN>CO>[NH2:15][CH2:14][C:13]1[CH:12]=[CH:11][C:10]([CH2:9][O:8][C:4]2[N:3]=[C:2]([NH2:1])[CH:7]=[CH:6][N:5]=2)=[CH:23][CH:22]=1

참가 물질

4

반응물 2

HCID 6329MethylamineHCID 86657016N-(4-((4-Aminopyrimidin-2-yloxy)methyl)benzyl)-2,2,2-trifluoroacetamide

생성물 1

HCID 584459102-((4-(Aminomethyl)benzyl)oxy)pyrimidin-4-amine

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

150 mg (0.46 mmol) of N-(4-((4-Aminopyrimidin-2-yloxy)methyl)benzyl)-2,2,2-trifluoro-acetamide (1) is dissolved in 2 mL methanol and treated with 5 mL methylamine (33% in ethanol). The reaction mixture is stirred at room temperature over night and all volatiles are removed in vacuo. The product is used without further purification in the next step. ESI-MS m/z 231 [M+H]+.

후처리

  1. customall volatiles are removed in vacuo
  2. customThe product is used without further purification in the next step

출처 및 근거

ORD 기록
ord-83c7c710bd684dcc953e77710828a7b4
출처 데이터셋
uspto-grants-2012_07
특허 번호
US08227602B2

반응 노트

불러오는 중…