1-[4-(Isobutylamino)-3-nitrophenyl]ethanone → 1-[3-Amino-4-(isobutylamino)phenyl]ethanone

HRID 1517182

반응식

HRID 1517182 반응식
[CH2:1]([NH:5][C:6]1[CH:11]=[CH:10][C:9]([C:12](=[O:14])[CH3:13])=[CH:8][C:7]=1[N+:15]([O-])=O)[CH:2]([CH3:4])[CH3:3]>CO.[Pd]>[NH2:15][C:7]1[CH:8]=[C:9]([C:12](=[O:14])[CH3:13])[CH:10]=[CH:11][C:6]=1[NH:5][CH2:1][CH:2]([CH3:3])[CH3:4]

참가 물질

4

반응물 1

HCID 595690481-[4-(Isobutylamino)-3-nitrophenyl]ethanone

생성물 1

HCID 595690101-[3-Amino-4-(isobutylamino)phenyl]ethanone수율 100%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

To a solution of 31.6 g (134 mM) of 1-[4-(isobutylamino)-3-nitrophenyl]-ethanone in 400 ml of methanol are added 3.2 g of 10% palladium-on-charcoal. The reaction medium is then placed under a hydrogen atmosphere at ambient pressure with vigorous stirring for 1 hour. The reaction medium is filtered through Celite and the solvent is evaporated off under vacuum to give 27.6 g of 1-[3-amino-4-(isobutylamino)phenyl]ethanone in quantitative yield, in the form of an oil.

후처리

  1. filtrationThe reaction medium is filtered through Celite
  2. customthe solvent is evaporated off under vacuum

출처 및 근거

ORD 기록
ord-5a2383039cfb4baaa21b514f761a8d28
출처 데이터셋
uspto-grants-2012_07
특허 번호
US08232272B2

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