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Diethyl Ether → 2-bromo-1-[1-isobutyl-2-(3-methoxyphenyl)-1H-benzimidazol-5-yl]ethanone hydrochloride

HRID 1517183
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반응식

HRID 1517183 반응식
[ClH:1].[CH2:2]([N:6]1[C:10]2[CH:11]=[CH:12][C:13]([C:15](=[O:17])[CH3:16])=[CH:14][C:9]=2[N:8]=[C:7]1[C:18]1[CH:23]=[CH:22][CH:21]=[C:20]([O:24][CH3:25])[CH:19]=1)[CH:3]([CH3:5])[CH3:4].[Br:26]Br.C(OCC)C>C(O)(=O)C>[ClH:1].[Br:26][CH2:16][C:15]([C:13]1[CH:12]=[CH:11][C:10]2[N:6]([CH2:2][CH:3]([CH3:4])[CH3:5])[C:7]([C:18]3[CH:23]=[CH:22][CH:21]=[C:20]([O:24][CH3:25])[CH:19]=3)=[N:8][C:9]=2[CH:14]=1)=[O:17]
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

5

반응물 3

HCID 3283Diethyl EtherHCID 24408BromineHCID 686437671-[1-Isobutyl-2-(3-methoxy phenyl)-1h-benzimidazol-5-yl]ethanone hydrochloride

생성물 1

HCID 866472782-bromo-1-[1-isobutyl-2-(3-methoxyphenyl)-1H-benzimidazol-5-yl]ethanone hydrochloride수율 63.2%

시약·촉매·용매 1

HCID 176Acetic Acid용매

실험 절차

To a solution of 32.7 g (91.3 mM) of 1-[1-isobutyl-2-(3-methoxy phenyl)-1H-benzimidazol-5-yl]ethanone hydrochloride in 330 ml of acetic acid are added dropwise 4.7 ml (91.4 mM) of bromine. 100 ml of diethyl ether are then added and the crystalline product is filtered off. It is washed with diethyl ether and dried under vacuum to give 35 g of 2-bromo-1-[1-isobutyl-2-(3-methoxyphenyl)-1H-benzimidazol-5-yl]ethanone hydrochloride.

후처리

  1. filtrationthe crystalline product is filtered off
  2. washIt is washed with diethyl ether
  3. customdried under vacuum

출처 및 근거

ORD 기록
ord-c0d94855e69047cdbc0ae5ed2fe9cd33
출처 데이터셋
uspto-grants-2012_07
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US08232272B2

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