Nitric Acid → N-(2-nitro-4-propanoylphenyl)acetamide

반응식

[C:1]([C:5]1[CH:10]=[CH:9][C:8]([NH:11][C:12](=[O:14])[CH3:13])=[CH:7][CH:6]=1)(=[O:4])[CH2:2][CH3:3].[N+:15]([O-])([OH:17])=[O:16]>>[N+:15]([C:7]1[CH:6]=[C:5]([C:1](=[O:4])[CH2:2][CH3:3])[CH:10]=[CH:9][C:8]=1[NH:11][C:12](=[O:14])[CH3:13])([O-:17])=[O:16]

참가 물질

반응물 2

HCID 944Nitric Acid

HCID 85655N-[4-(1-oxopropyl)phenyl]acetamide

생성물 1

HCID 59569038N-(2-nitro-4-propanoylphenyl)acetamide

반응 조건

온도: -20 °C

실험 절차

To 140 ml of nitric acid are added portionwise, while maintaining the temperature at −20° C., 37.8 g (198 mM) of N-(4-propanoylphenyl)acetamide. The reaction medium is then poured into a water/ice mixture. The solid that precipitates out is filtered off and washed with water to give, after drying, 37.6 g of N-(2-nitro-4-propanoylphenyl)acetamide in the form of a pale yellow solid.

후처리

customThe solid that precipitates out
filtrationis filtered off
washwashed with water
customto give
customafter drying

출처 및 근거

ORD 기록: ord-41d0d4c94496460aa197a33c470bec73
출처 데이터셋: uspto-grants-2012_07
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08232272B2

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