Tetrahydrofuran → 6-Fluoro-5-methylpyridin-3-ol

HRID 1517287

반응식

HRID 1517287 반응식
O.OO.[O:4]1CCCC1.[F:9][C:10]1[C:15]([CH3:16])=[CH:14][C:13](B(O)O)=[CH:12][N:11]=1>O>[F:9][C:10]1[N:11]=[CH:12][C:13]([OH:4])=[CH:14][C:15]=1[CH3:16]

참가 물질

5

반응물 3

HCID 8028TetrahydrofuranHCID 449047Hydrogen peroxide waterHCID 17750247(6-Fluoro-5-methylpyridin-3-yl)boronic acid

생성물 1

HCID 229897166-Fluoro-5-methylpyridin-3-ol수율 96%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

Hydrogen peroxide water (4.37 ml, 42.8 mmol) was added to a tetrahydrofuran solution (50 ml) of 2-fluoro-3-methylpyridine-5-boronic acid (5.1 g, 32.9 mmol), and stirred overnight at room temperature. Water was added to the reaction solution, and extracted with ethyl acetate. The organic layer was washed with aqueous 5% sodium thiosulfate solution and saturated saline water, dried over anhydrous sodium sulfate, and concentrated under reduced pressure to obtain 6-fluoro-5-methylpyridin-3-ol (4.03 g, yield: 96%) as a pale yellow solid.

후처리

  1. extractionextracted with ethyl acetate
  2. washThe organic layer was washed with aqueous 5% sodium thiosulfate solution and saturated saline water
  3. dry with materialdried over anhydrous sodium sulfate
  4. concentrationconcentrated under reduced pressure

출처 및 근거

ORD 기록
ord-b8e9a31285f1488e942a777094ac20da
출처 데이터셋
uspto-grants-2012_07
특허 번호
US08232284B2

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