Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Dimethylamine tetrahydrofuran → 6-({5-[2-(dimethylamino)ethoxy]pyridin-2-yl}oxy)-N-pyrazin-2-ylquinazoline-4-amine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Dimethylamine tetrahydrofuran | HCID 22320367 | — |
| 반응물 | 5-(2,2-Diethoxyethoxy)-2-fluoropyridine | HCID 68429706 | — |
| 반응물 | 4-(Pyrazin-2-ylamino)quinazolin-6-ol | HCID 136334744 | — |
| 생성물 | 6-({5-[2-(dimethylamino)ethoxy]pyridin-2-yl}oxy)-N-pyrazin-2-ylquinazoline-4-amine | HCID 59508840 | — |
반응 단계
Using 4-(pyrazin-2-ylamino)quinazolin-6-ol, 5-(2,2-diethoxyethoxy)-2-fluoropyridine and 2 M dimethylamine/tetrahydrofuran solution, and in the same manner as in Example 31 or according to a method similar to it or according to a combination thereof with an ordinary method, the entitled compound (13 mg) was obtained as a pale yellow amorphous solid.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08232284B2 |
| 출처 데이터셋 | uspto-grants-2012_07 |
| ORD ID | ord-fae794a0e6cf43e992b2bbac95053897 |
| 출처 메모 | uspto-grants-2012_07 |