Piperazine → HCID 68843659, 화합물

HRID 1517400노트

반응식

HRID 1517400 반응식
[NH:1]1[CH2:6][CH2:5][NH:4][CH2:3][CH2:2]1.[C:7]([NH:10][C:11]1[N:12]=[C:13](C2N=CNN=2)[C:14]2[N:20]=[C:19]([C:21]3[CH:26]=[CH:25][C:24]([O:27][CH3:28])=[C:23]([O:29][CH3:30])[CH:22]=3)[CH:18]=[CH:17][C:15]=2[N:16]=1)(=[O:9])[CH3:8]>O1CCOCC1>[C:7]([NH:10][C:11]1[N:12]=[C:13]([N:1]2[CH2:6][CH2:5][NH:4][CH2:3][CH2:2]2)[C:14]2[N:20]=[C:19]([C:21]3[CH:26]=[CH:25][C:24]([O:27][CH3:28])=[C:23]([O:29][CH3:30])[CH:22]=3)[CH:18]=[CH:17][C:15]=2[N:16]=1)(=[O:9])[CH3:8]

참가 물질

4

반응물 2

HCID 4837PiperazineHCID 178488517HCID 178488517, 화합물

생성물 1

HCID 68843659HCID 68843659, 화합물수율 79%

시약·촉매·용매 1

HCID 312751,4-Dioxane용매

실험 절차

Piperazine (430 mg, 5 mmole) was added to a stirred suspension of 2-acetamido-6-(3,4-dimethoxyphenyl)-4-(1,2,4-triazolyl)pyrido[3,2-d]pyrimidine (977 mg, 2.5 mmole) in dioxane (70 ml). The reaction mixture was refluxed for 16 hours. The precipitate was filtered off and washed with a small amount of dioxane. The filtrate was evaporated to dryness and the residue washed with diethyl ether. Both fractions (the precipitate and the washed filtrate) were combined, resulting in the pure title compound (805 mg, yield 79%) which was characterized by its mass spectrum as follows: MS (m/z): 409 ([M+H]+, 100).

후처리

  1. temperatureThe reaction mixture was refluxed for 16 hours
  2. filtrationThe precipitate was filtered off
  3. washwashed with a small amount of dioxane
  4. customThe filtrate was evaporated to dryness
  5. washthe residue washed with diethyl ether

출처 및 근거

ORD 기록
ord-21f6ffaa6cf846318ced0ce1dd2c8f18
출처 데이터셋
uspto-grants-2012_07
특허 번호
US08232278B2

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