Ammonia → 6-(4-Fluorophenyl)pyrido[3,2-d]pyrimidin-4-amine

HRID 1517439노트

반응식

HRID 1517439 반응식
[NH3:1].Cl[C:3]1[C:4]2[N:12]=[C:11]([C:13]3[CH:18]=[CH:17][C:16]([F:19])=[CH:15][CH:14]=3)[CH:10]=[CH:9][C:5]=2[N:6]=[CH:7][N:8]=1>CO>[NH2:1][C:3]1[C:4]2[N:12]=[C:11]([C:13]3[CH:18]=[CH:17][C:16]([F:19])=[CH:15][CH:14]=3)[CH:10]=[CH:9][C:5]=2[N:6]=[CH:7][N:8]=1

참가 물질

4

반응물 2

HCID 222AmmoniaHCID 579067564-Chloro-6-(4-fluorophenyl)pyrido[3,2-d]pyrimidine

생성물 1

HCID 576983546-(4-Fluorophenyl)pyrido[3,2-d]pyrimidin-4-amine수율 83%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

To an ammonia solution in methanol (5 ml of a 6 M solution) was added 4-chloro-6-(4-fluorophenyl)-pyrido[3,2-d]pyrimidine (26 mg, 0.1 mmol). The mixture was stirred at room temperature for 12 hours. After concentration under reduced pressure, the residue was purified by silica gel flash chromatography, the mobile phase being a mixture of methanol and dichloromethane, in a volume ratio of 1:30, yielding the title compound (20 mg, yield 83%) as a white solid which was characterised by its mass spectrum as follows: MS (m/z): 241 ([M+H]+, 100).

후처리

  1. concentrationAfter concentration under reduced pressure
  2. customthe residue was purified by silica gel flash chromatography
  3. additiona mixture of methanol and dichloromethane

출처 및 근거

ORD 기록
ord-c8c1b32e1e9649d1ae86b1ca3628fc0c
출처 데이터셋
uspto-grants-2012_07
특허 번호
US08232278B2

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