Morpholine → 6-Chloro-4-(morpholin-4-yl)pyrido[3,2-d]pyrimidin-2-amine

HRID 1517460노트

반응식

HRID 1517460 반응식
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[N:6]=[C:7]([NH2:17])[N:8]=[C:9]([N:12]3[CH:16]=NC=N3)[C:10]=2[N:11]=1.N1C[CH2:22][O:21][CH2:20][CH2:19]1>C(Cl)Cl>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[N:6]=[C:7]([NH2:17])[N:8]=[C:9]([N:12]3[CH2:16][CH2:22][O:21][CH2:20][CH2:19]3)[C:10]=2[N:11]=1

참가 물질

4

반응물 2

HCID 8083MorpholineHCID 576983146-Chloro-4-(1H-1,2,4-triazol-1-yl)pyrido[3,2-d]pyrimidin-2-amine

생성물 1

HCID 576983306-Chloro-4-(morpholin-4-yl)pyrido[3,2-d]pyrimidin-2-amine수율 244.6%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

A suspension of 6-chloro-4-[1,2,4]triazol-1-yl-pyrido[3,2-d]pyrimidin-2-ylamine (0.1 g, 0.4 mmol) and morpholine (0.07 mL, 0.8 mmol) in DCM (10 mL) was stirred at room temperature for 48 hours. After the removal of solvent, the residue was purified by flash chromatography (using 5% i-PrOH/DCM as the eluent), providing the title compound (0.26 g, 99% yield) as a yellow solid which was characterised as follows: MS (m/z) 266.0 [M+H]+.

후처리

  1. customAfter the removal of solvent
  2. customthe residue was purified by flash chromatography (

출처 및 근거

ORD 기록
ord-9192569dccb84dbf97a5d896373e223e
출처 데이터셋
uspto-grants-2012_07
특허 번호
US08232278B2

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