Bromine → HCID 67374784, 화합물

HRID 1517549노트

반응식

HRID 1517549 반응식
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:9]=[CH:10][C:11]=1[C:12]([CH3:15])([CH3:14])[CH3:13])[C:6]([OH:8])=[O:7].CC([O-])=O.[Na+].[Br:21]Br>CC(O)=O>[Br:21][C:9]1[C:5]([C:6]([OH:8])=[O:7])=[CH:4][C:3]([O:2][CH3:1])=[C:11]([C:12]([CH3:15])([CH3:14])[CH3:13])[CH:10]=1

참가 물질

5

반응물 3

HCID 24408BromineHCID 517045Sodium AcetateHCID 127397584-tert-Butyl-3-methoxybenzoic acid

생성물 1

HCID 67374784HCID 67374784, 화합물

시약·촉매·용매 1

HCID 176Acetic Acid용매

반응 조건

온도
50 °C

실험 절차

step 1—To a solution of 3-methoxy-4-tert-butylbenzoic acid (1.0 eq, 48.02 mmol, 10.00 g and NaOAc (2.0 eq, 96.03 mmol, 7.88 g) in HOAc (75 mL) at RT was added dropwise Br2 (2.0 eq, 96.03 mmol, 4.94 mL). The resulting mixture was heated at 50° C. for 24 h, cooled to RT and poured into a mixture of ice-water. The slightly orange-colored solid was collected by suction filtration, washed with water, dried in the oven at 40° C. to afford 12.87 g of 6-bromo-4-tert-butyl-3-methoxybenzoic acid the product (118).

후처리

  1. temperaturecooled to RT
  2. filtrationThe slightly orange-colored solid was collected by suction filtration
  3. washwashed with water
  4. customdried in the oven at 40° C.

출처 및 근거

ORD 기록
ord-b87c6be46afa4d1b82056429a0d9c82e
출처 데이터셋
uspto-grants-2012_07
특허 번호
US08232271B2

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